Automated Microfluidic Technology:
HOW IT WORKS

Traditional cell isolation methods such as density gradient centrifugation are time-consuming and do not deliver the consistency and performance you need. Our innovative cell isolation technology addresses the performance gap, delivering automated processing for significant advantages over conventional methods.

PURITY

Consistently high yield of your target cell population

PERFORMANCE

Viable and functional cells in only a few steps

RELIABILITY

Reproducible results across diverse donor types

Microfluidic Technology
IN ACTION

See how to achieve precise cell isolation.

Typical MicroMedicine Results

95%

purity of nucleated cells and no failed separations

.01%

platelet carryover

.01%

red blood cell carryover

150 mL/HOUR or over 200 MILLION CELLS/SECOND

Microfluidic Technology:
STEP-BY-STEP

MicroMedicine’s technology centers around a high-precision, microfluidic disc (formerly LeukoChip®) for rapid enrichment of target cells. Using physics to leverage small differences in cell size, this size-based isolation leads to reliable cell separation. Each cell spends a small fraction of a second in the microfluidic disc, minimizing physical and chemical manipulation typical of traditional methods. Achieve precise, consistent cell enrichment to enhance performance and quality of information in your research. The novel technology has promising applications in clinical diagnostics and cell therapy.

1 The Filter Stage

The on-disc filter removes debris such as clots, fibrin, and bone spicules to keep the sample flowing smoothly through the device.

2 The Cell Sorter Stage

The sample stream enters a microfluidic channel flowing alongside a buffer stream. Within the channel, precisely engineered island structures exert a fluidic lift force, sorting your target cells by size. Target cells migrate from the sample stream into the buffer stream, leaving contaminating cells behind.

3 The Concentrator Stage

The target cells move into curving channels, where fluidic lift forces then assemble the cell into a tight stream. This creates a cell-free buffer stream that is siphoned off to waste. Exiting the microfluidic disc, your target cells have been concentrated over tenfold compared to the input volume.