Automated Microfluidic Technology:
HOW IT WORKS
Traditional cell isolation methods such as density gradient centrifugation are time-consuming and do not deliver the consistency and performance you need. Our innovative cell isolation technology addresses the performance gap, delivering automated processing for significant advantages over conventional methods.
Consistently high yield of your target cell population
Viable and functional cells in only a few steps
Reproducible results across diverse donor types
Typical MicroMedicine Results
purity of nucleated cells and no failed separations
red blood cell carryover
150 mL/HOUR or over 200 MILLION CELLS/SECOND
MicroMedicine’s technology centers around a high-precision, microfluidic disc (formerly LeukoChip®) for rapid enrichment of target cells. Using physics to leverage small differences in cell size, this size-based isolation leads to reliable cell separation. Each cell spends a small fraction of a second in the microfluidic disc, minimizing physical and chemical manipulation typical of traditional methods. Achieve precise, consistent cell enrichment to enhance performance and quality of information in your research. The novel technology has promising applications in clinical diagnostics and cell therapy.
1 The Filter Stage
The on-disc filter removes debris such as clots, fibrin, and bone spicules to keep the sample flowing smoothly through the device.
2 The Cell Sorter Stage
The sample stream enters a microfluidic channel flowing alongside a buffer stream. Within the channel, precisely engineered island structures exert a fluidic lift force, sorting your target cells by size. Target cells migrate from the sample stream into the buffer stream, leaving contaminating cells behind.
3 The Concentrator Stage
The target cells move into curving channels, where fluidic lift forces then assemble the cell into a tight stream. This creates a cell-free buffer stream that is siphoned off to waste. Exiting the microfluidic disc, your target cells have been concentrated over tenfold compared to the input volume.